We had the good fortune of connecting with Melanie Mancil and we’ve shared our conversation below.

Hi Melanie, what is the most important factor behind your success?
The most important factor behind my success is my unwavering commitment to truly understanding and empowering my patients on their wellness journeys.
At Twelve28 Health and Wellness Center, I’m on a mission to redefine what wellness means. Here, we don’t just treat symptoms; we dig deeper, exploring the root causes of health concerns to create highly individualized treatment plans that are as unique as the people who walk through our doors.

We take a functional medicine approach that beautifully blends the best of traditional healthcare with cutting-edge diagnostics, all while honoring a holistic view of wellness. I look beyond the basics, studying how genetics, lifestyle, and environment intersect to shape each patient’s health. From hormone balance to metabolic support and managing chronic conditions, my goal is simple: to help every patient feel their best from the inside out.

This isn’t about a “quick fix.” At Twelve28, we’re here to help you embrace sustainable, lifestyle-centered solutions that empower you to take the reins of your wellness journey. My commitment isn’t just to relieve symptoms—it’s to foster a deep understanding of your health, guiding you toward lasting vitality. Twelve28 is more than a clinic; it’s a partner devoted to helping you thrive.

This dedication to individualized care and sustainable health solutions is the foundation of everything we do at Twelve28, and it’s what allows us to redefine success—not just in health outcomes, but in the lives we touch.

What should our readers know about your business?
The heart of my practice is honesty. Since day one, I’ve believed that trust starts with transparency. I’m not one to sugarcoat; I tell it like it is, building an open, trusting relationship that’s essential when it comes to something as important as your health. My patients know they can count on me—not just because of what I say, but because they can reach me anytime, day or night. My personal cell number is theirs, reflecting my commitment to their journey and my promise to be there, every step of the way.

Among the services we offer, weight loss transformations are closest to my heart. Watching patients overcome the habits that have held them back, from diet and sleep to stress, is endlessly fulfilling. There’s nothing like witnessing a patient’s transformation—not only in body but in spirit. And often, these changes inspire healthier lifestyles for their families, creating a ripple effect that fills me with pride and joy.

One thing that surprises people is that Twelve28 Health and Wellness Center has grown entirely through referrals. No ads, just the trust my patients share with their friends and families. This means the world to me; it’s a testament to the genuine connections I’ve built with each patient.

Of course, every field has its challenges. For me, it’s the overwhelming misinformation online. These days, anyone can publish health information, and so much of it lacks real science. My role is to arm my patients with knowledge they can trust. I stay on top of the latest by attending medical conferences, analyzing the newest studies, and learning from my daily patient interactions. My goal is to cut through the noise and guide patients with insights grounded in evidence and care.

If you had a friend visiting you, what are some of the local spots you’d want to take them around to?
When friends visit, I make sure they experience the best of Los Angeles! I’d start with the speakeasy at The Georgian in Santa Monica. This hidden spot transports you back to the 1920s, with a “no cell phone” policy that makes you truly live in the moment. My chosen niece, Sierra Fisher, performs here, filling the room with soulful, timeless music. Next stop? Taverna Tony in Malibu—a local favorite with authentic Greek food, live music, and a lively atmosphere that’s just perfect for a night out.

For a relaxed afternoon, we’d head to Malibu Pier. Lunch here is always a treat: amazing food, ocean views, and plenty of people-watching. The rest of the week? A blend of coastal drives, sunset cocktails, art galleries, and hidden boutiques—every day here has the makings of a new adventure, and I’m always excited to share it with those I love.

The Shoutout series is all about recognizing that our success and where we are in life is at least somewhat thanks to the efforts, support, mentorship, love and encouragement of others. So is there someone that you want to dedicate your shoutout to?
I owe so much of my journey to the unwavering support and encouragement of my family and the incredible patients who walk through the doors of Twelve28 Health and Wellness Center. My family has been my rock, standing by me in moments of doubt and celebrating every small victory with genuine joy. Their love and belief in my vision fuel me daily, inspiring me to give my best to others. They’ve shown me the importance of balance, compassion, and resilience, qualities I hope to pass on to each patient I serve.

And to my patients—there simply are no words to fully express my gratitude. You trust me with your stories, your fears, your dreams, and the deepest parts of your health journeys. You inspire me constantly with your courage to make changes, to choose health even when it’s hard, and to embrace growth in every sense. Watching you transform your lives and witness the ripple effect of wellness on your families is the most fulfilling part of my work.

Thank you, my family and my patients, for being my motivation and my grounding force. You are the heart of Twelve28 Health and Wellness Center, and you remind me every day why I do what I do.

Website: https://twelve-28.com/pages/meet-the-team

Instagram: https://www.instagram.com/twelve20eight?igsh=MzRlODBiNWFlZA==

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